sysVASC is a bench to bedside project with a systems biology approach to identify molecular targets for vascular disease treatment

Cardiovascular disease, or CVD, refers to a variety of health problems with the heart or blood vessels, including heart attacks, heart failure and stroke. Together they are the number one cause of death globally. The underlying defects remain incompletely understood and asymptomatic vascular damage can accumulate for years before patients are diagnosed.

The aim of the EU-funded project sysVASC was to use a systems medicine approach to better understand the development of CVD and to find molecular targets, so called biomarkers, for earlier diagnosis and therapeutic intervention.

The sysVASC consortium has made great progress towards this goal with the generation and integration of omics data into both a public CVD Knowledgebase (http://cvdkb.org/home.html) and consortial databases describing the molecular phenotype of progressive CVD. Modelling tools have been developed to reveal key molecular nodes underlying disease progression with valuable insights already resulting from the validation of these targets.

sysVASC project concluded

After 48 months, the sysVASC project came to a scheduled end on 31st January 2018. The consortium remains engaged in the area of CVD research and will continue to exploit the achievements for clinical applications with the vision to improve management of CVD.

 

NEWS

Cardiovascular disease (CVD)

CVD is currently the leading cause of death worldwide with more than 40 % of deaths in the EU attributed to them.

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SPOTLIGHT
Prof. Burkert Pieske, MD
Coordinator

Burkert Pieske is the principal investigator of several ongoing inpatient and outpatient cohorts and clinical phase I to IV trials with a primary focus on heart failure.

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