sysVASC is a bench to bedside project with a systems biology approach to identify molecular targets for vascular disease treatment
Cardiovascular disease, or CVD, refers to a variety of health problems with the heart or blood vessels, including heart attacks, heart failure and stroke. Together they are the number one cause of death globally. The underlying defects remain incompletely understood and asymptomatic vascular damage can accumulate for years before patients are diagnosed.
The aim of the EU-funded project sysVASC was to use a systems medicine approach to better understand the development of CVD and to find molecular targets, so called biomarkers, for earlier diagnosis and therapeutic intervention.
The sysVASC consortium has made great progress towards this goal with the generation and integration of omics data into both a public CVD Knowledgebase (http://cvdkb.org/home.html) and consortial databases describing the molecular phenotype of progressive CVD. Modelling tools have been developed to reveal key molecular nodes underlying disease progression with valuable insights already resulting from the validation of these targets.