PUBLICATIONS

APR 2017
Increased urine acylcarnitines in diabetic ApoE-/- mice: Hydroxytetradecadienoylcarnitine (C14:2-OH) reflects diabetic nephropathy in a context of hyperlipidemia.

Mirzoyan K, Klavins K, Koal T, Gillet M, Marsal D, Denis C, Klein J, Bascands JL, Schanstra JP, Saulnier-Blache JS. Biochemical and Biophysical Research Communications. 2017 Apr 7; pii: S0006-291X(17)30682-4. [Epub ahead of print]

sysVASC Partner: INSERM, BIOCRATES
https://www.ncbi.nlm.nih.gov/pubmed/28396151


MAR 2017
DNA methylation signatures in peripheral blood strongly predict all-cause mortality.

Zhang Y, Wilson R, Heiss J, Breitling LP, Saum KU, Schöttker B, Holleczek B, Waldenberger M, Peters A, Brenner H. Nature Communications. 2017 Mar 17;8:14617.

sysVASC Partner: HMGU
https://www.ncbi.nlm.nih.gov/pubmed/28303888


MAR 2017
Inhibition of osteo/chondrogenic transformation of vascular smooth muscle cells by MgCl2 via calcium-sensing receptor.

Alesutan I, Tuffaha R, Auer T, Feger M, Pieske B, Lang F, Voelkl J. Journal of Hypertension. 2017 Mar; 35(3):523-532. Epub 2016 Dec 15.

sysVASC Partner: EKUT and CHA
https://www.ncbi.nlm.nih.gov/pubmed/27984337


FEB 2017
Proteomics in cardiovascular disease: recent progress and clinical implication and implementation.

Mokou M, Lygirou V, Vlahou A, Mischak H. Expert Review of Proteomics. 2017 Feb;14(2):117-136. Epub 2017 Jan 5.

sysVASC Partner: BRFAA and MOS
https://www.ncbi.nlm.nih.gov/pubmed/27997814


DEC 2016
Characterization of poplar metabotypes via mass difference enrichment analysis.

Moritz F, Kaling M, Schmitt-Kopplin P, Schnitzler J-P. Plant, Cell & Environment. 2016; Epub 2016 Dec 11.

sysVASC Partner: HMGU
http://www.ncbi.nlm.nih.gov/pubmed/27943315


DEC 2016
Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease.

Stanley E, Delatola EI, Nkuipou-Kenfack E, Spooner W, Kolch W, Schanstra JP, Mischak H and Koeck T. BMC Bioinformatics. 2016; 17: 496.

sysVASC Partner: EAG, NUID UCD, MOS and INSERM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139137/


DEC 2016
The Future of "Omics" in Hypertension.

Currie G, Delles C. Canadian Journal of Cardiology. 2016. Dec 7 (Epub ahead of print).

sysVASC Partner: GLA
https://www.ncbi.nlm.nih.gov/pubmed/28161100


DEC 2016
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL; WHI-EMPC Investigators, Fiorito G; CHARGE epigenetics of Coronary Heart Disease, Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A. Genome Biology. 2016 Dec 12;17(1):255.

sysVASC Partner: HMGU
https://www.ncbi.nlm.nih.gov/pubmed/27955697


NOV 2016
Urinary Proteomics for Diagnosis and Monitoring of Diabetic Nephropathy.

Currie G, Delles C. Current Diabetes Reports. 2016 Nov;16(11):104.

sysVASC Partner: GLA
https://www.ncbi.nlm.nih.gov/pubmed/27658932


NOV 2016
Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases.

Magalhães P, Mischak H, Zürbig P. Current Opinion in Nephrology and Hypertension. 2016 Nov; 25(6):494-501.

sysVASC Partner: MOS
https://www.ncbi.nlm.nih.gov/pubmed/27584928


NOV 2016
A DNA methylation biomarker of alcohol consumption.

Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG, Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kühnel B, Herder C, Almli LM, Zhi D, Wang Y, Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA, Guan W, Shah S, McRae AF, Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL, Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D, Ferrucci L, Bandinelli S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L, Uitterlinden AG, Yet I, Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JB, Conneely KN, Baccarelli AA, Deary IJ, Bell JT, North KE, Liu Y, Waldenberger M, London SJ, Ingelsson E, Levy D. Molecular Psychiatry. 2016 Nov 15.

sysVASC Partner: HMGU
https://www.ncbi.nlm.nih.gov/pubmed/27843151


NOV 2016
Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues.

Marzi C, Holdt LM, Fiorito G, Tsai PC, Kretschmer A, Wahl S, Guarrera S, Teupser D, Spector TD, Iacoviello L, Sacerdote C, Strauch K, Lee S, Thasler WE, Peters A, Thorand B, Wolf P, Prokisch H, Tumino R, Gieger C, Krogh V, Panico S, Bell JT, Matullo G, Waldenberger M, Grallert H, Koenig W. PLoS One. 2016 Nov 8;11(11):e0166015.

sysVASC Partner: HMGU
https://www.ncbi.nlm.nih.gov/pubmed/27824951


OCT 2016
Epigenetic Signatures of Cigarette Smoking.

Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Circulation Cardiovascular Genetics. 2016 Oct;9(5):436-447. Epub 2016 Sep 20.

sysVASC Partner: HMGU
https://www.ncbi.nlm.nih.gov/pubmed/27651444


AUG 2016
AMP-activated protein kinase α1-sensitive activation of AP-1 in cardiomyocytes.

Voelkl J, Alesutan I, Primessnig U, Feger M, Mia S, Jungmann A, Castor T, Viereck R, Stöckigt F, Borst O, Gawaz M, Schrickel JW, Metzler B, Katus HA, Müller OJ, Pieske B, Heinzel FR, Lang F. Journal of Molecular and Cellular Cardiology. 2016 Aug; 97:36-43. Epub 2016 Apr 19.

sysVASC Partner: EKUT, CHA and MUG
https://www.ncbi.nlm.nih.gov/pubmed/27106803


AUG 2016
Systematic Review of Micro-RNA Expression in Pre-Eclampsia Identifies a Number of Common Pathways Associated with the Disease.

Sheikh AM, Small HY, Currie G, Delles C. PLoS One. 2016 Aug 16;11(8):e0160808.

sysVASC Partner: GLA
https://www.ncbi.nlm.nih.gov/pubmed/27529341


JUL 2016
A Bayesian algorithm for detecting differentially expressed proteins and its application in breast cancer research.

Santra T, Delatola EI. Scientific Reports. 2016 Jul 22;6:30159.

sysVASC Partner: NUID UCD
https://www.ncbi.nlm.nih.gov/pubmed/27444576


JUL 2016
Use of Biomarkers in the Evaluation and Treatment of Hypertensive Patients.

Currie G, Delles C. Current Hypertension Reports. 2016 Jul;18(7):54.

sysVASC Partner: GLA
https://www.ncbi.nlm.nih.gov/pubmed/27221728


JUN 2016
Augmentation of phosphate-induced osteo-/chondrogenic transformation of vascular smooth muscle cells by homoarginine.

Alesutan I, Feger M, Tuffaha R, Castor T, Musculus K, Buehling SS, Heine CL, Kuro-O M, Pieske B, Schmidt K, Tomaschitz A, Maerz W, Pilz S, Meinitzer A, Voelkl J, Lang F. Cardiovascular Research. 2016 Jun 1;110(3):408-18. Epub 2016 Mar 21.

sysVASC Partner: EKUT, MUG and CHA
https://www.ncbi.nlm.nih.gov/pubmed/27001421


JUN 2016
The Proteasix Ontology.

Arguello Casteleiro M, Klein J, Stevens R. Journal Biomedical Semantics. 2016 Jun; 4;7(1):33.

sysVASC Partner: UNIMAN and INSERM
http://www.ncbi.nlm.nih.gov/pubmed/27259807


MAR 2016
The role of urinary peptidomics in kidney disease research.

Klein J, Bascands JL, Mischak H, Schanstra JP. Kidney International. 2016 Mar; 89(3):539-45. Epub 2016 Jan 14.

sysVASC Partner: INSERM and MOS
http://www.ncbi.nlm.nih.gov/pubmed/26880450


FEB 2016
Prostasin, proteases, and preeclampsia.

Small HY, Currie GE, Delles C. Journal of Hypertension. 2016 Feb;34(2):193-5.

sysVASC Partner: GLA
https://www.ncbi.nlm.nih.gov/pubmed/26682786


NOV 2015
New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis.

Glorieux G, Mullen W, Duranton F, Filip S, Gayrard N, Husi H, Schepers E, Neirynck N, Schanstra JP, Jankowski J, Mischak H, Argilés À, Vanholder R, Vlahou A, Klein J. Nephrology Dialysis Transplantation. 2015 Nov; 30(11):1842-52. Epub 2015 Jul 9.

sysVASC Partner: GLA, BRFAA, CHA, INSERM, MOS and UOP
https://www.ncbi.nlm.nih.gov/pubmed/26160894


OCT 2015
Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine.

Alesutan I, Musculus K, Castor T, Alzoubi K, Voelkl J, Lang F. Kidney and Blood Pressure Research. 2015 Oct; 40(5):490-9. Epub 2015 Sep 30.

sysVASC Partner: EKUT
http://www.ncbi.nlm.nih.gov/pubmed/26418500


OCT 2015
NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency.

Leibrock CB, Alesutan I, Voelkl J, Pakladok T, Michael D, Schleicher E, Kamyabi-Moghaddam Z, Quintanilla-Martinez L, Kuro-O M, Lang F. Journal of the American Society of Nephrology. 2015 Oct; 26(10):2423-33. Epub 2015 Feb 2.

sysVASC Partner: EKUT
http://www.ncbi.nlm.nih.gov/pubmed/25644113


SEP 2015
Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.

Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR; American Heart Association Council on Functional Genomics and Translational Biology, Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Hypertension, and Stroke Council. Circulation. 2015 Sep 1;132(9):852-72. Epub 2015 Jul 20.

sysVASC Partner: GLA
https://www.ncbi.nlm.nih.gov/pubmed/26195497


AUG 2015
Body fluid peptide and protein signatures in diabetic kidney diseases.

Jankowski J, Schanstra JP, Mischak H. Nephrology Dialysis Transplantation. 2015 Aug;30 Suppl 4:iv43-53.

sysVASC Partner: INSERM and MOS
https://www.ncbi.nlm.nih.gov/pubmed/26209737


JUN 2015
Capillary zone electrophoresis on-line coupled to mass spectrometry: a perspective application for clinical proteomics.

Pejchinovski M, Hrnjez D, Ramírez-Torres A, Bitsika V, Mermelekas G, Vlahou A, Zürbig P, Mischak H, Metzger J, Koeck T. Proteomics Clinical Applications. 2015 Jun; 9(5-6):453-68. Epub 2015 Apr 7.

sysVASC Partner: MOS and BRFAA
http://www.ncbi.nlm.nih.gov/pubmed/25641766


APR 2015
DNA methylation of lipid-related genes affects blood lipid levels.

Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, Klopp N, Illig T, Hedman ÅK, Roden M, Hernandez DG, Singleton AB, Thasler WE, Grallert H, Gieger C, Herder C, Teupser D, Meisinger C, Spector TD, Kronenberg F, Prokisch H, Melzer D, Peters A, Deloukas P, Ferrucci L, Waldenberger M. Circulation: Cardiovascular Genetics. 2015 Apr; 8(2):334-42. Epub 2015 Jan 12

sysVASC Partner: HMGU
http://www.ncbi.nlm.nih.gov/pubmed/25583993


APR 2015
Proteomic biomarkers in kidney disease: issues in development and implementation.

Mischak H, Delles C, Vlahou A, Vanholder R. Nature Reviews Nephrology. 2015 Apr; 11(4):221-32. Epub 2015 Feb 3

sysVASC Partner: MOS, GLA and BRFAA
http://www.ncbi.nlm.nih.gov/pubmed/25643662


APR 2015
CE-MS-based proteomics in biomarker discovery and clinical application.

Pontillo C, Filip S, Borràs DM, Mullen W, Vlahou A, Mischak H. Proteomics Clinical Applications. 2015 Apr; 9(3-4):322-34. Epub 2015 Mar 24.

sysVASC Partner: MOS, BRFAA and CHA
http://www.ncbi.nlm.nih.gov/pubmed/25641774


APR 2015
Pro: urine proteomics as a liquid kidney biopsy: no more kidney punctures!

Mischak H. Nephrology Dialysis Transplantation. 2015 Apr; 30(4):532-7.

sysVASC Partner: MOS, GLA
https://www.ncbi.nlm.nih.gov/pubmed/25801638


JAN 2015
AMP-activated protein kinase α1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload.

Alesutan I, Voelkl J, Stöckigt F, Mia S, Feger M, Primessnig U, Sopjani M, Munoz C, Borst O, Gawaz M, Pieske B, Metzler B, Heinzel F, Schrickel JW, Lang F. Cell Physiology and Biochemistry. 2015 Jan; 35(1):406-18. Epub 2015 Jan 14.

sysVASC Partner: EKUT
http://www.ncbi.nlm.nih.gov/pubmed/25591781


OCT 2014
Advances in urinary proteome analysis and applications in systems biology.

Filip S, Zoidakis J, Vlahou A, Mischak H. Bioanalysis. 2014 Oct;6(19):2549-69.

sysVASC Partner: MOS and BRFAA
http://www.ncbi.nlm.nih.gov/pubmed/25411698


OCT 2014
Urinary proteomics and molecular determinants of chronic kidney disease: possible link to proteases.

Filip S, Pontillo C, Peter Schanstra J, Vlahou A, Mischak H, Klein J. Expert Review of Proteomics. 2014 Oct;11(5):535-48. Epub 2014 Jun 24.

sysVASC Partner: MOS, BRFAA and INSERM
http://www.ncbi.nlm.nih.gov/pubmed/24957818

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