The University of British Columbia, Centre for Blood Research (CBR) is a multidisciplinary biomedical research institute with over 40 research groups in a broad range of fields from basic science to clinical investigative approaches on blood and blood-related processes. It is a leader in the assessment of proteases and protease networks.

Within the sysVASC project, the University of British Columbia will contribute expertise and train sysVASC partners in proteomics methods related to degradomics and the identification of protease-substrate relationships in vivo.

© Chris Overall

Prof. Chris Overall

Chris Overall is a Tier1 Canada research chair in Metalloproteinase Proteomics and Systems Biology at the Centre for Blood Research. His post-doctoral work was performed with Nobel laureate, Dr. Michael Smith. Chris Overall is highly influential in the field of proteomics with 197 publications and is the pioneer of the field of degradomics. His work has received wide recognition by the International Society of Proteolysis with a Lifetime Achievement Award among numerous others.


© Wikimedia Commons



1 a.d. Keller, U., et al. (2013). Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation. Science Signaling 6, 1-15.

2 Kleifeld, O, et al. (2011) System-Wide Proteomic Identification of Protease Cleavage Products by Terminal Amine Isotopic Labeling of Substrates. Nature Protocols. 6, 1578-611.

3 Schilling, O., et al. (2011). Characterization of Active Site Specificities of Proteases by Proteome-derived Peptide Libraries and Tandem Mass Spectrometry. Nature Protocols 6, 111–120.

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.